12.30-1.30pm, Wed 27th April 2016
Seminar Room 515, Level 5, 207 Bouverie Street, Carlton
Professor David Balding, Director, Centre for Systems Genomics, The University of Melbourne
Estimating heritability from genome-wide SNPs (single nucleotide polymorphisms) has been revolutionary since first introduced in 2010, leading to many publications and extensions of the original idea, particularly to understanding the heritability contributions of genomic regions and individual genes. There has also been some reaction recently, with papers critical of the method being published in prestigious journals. I will review the basic ideas and show that most of the high-profile criticisms have little merit, but that the method does rest on implicit assumptions that do not reflect reality, so that most published results under-estimate the heritability tagged by SNPs.