Penis development and hypospadias
Hypospadias is a disorder of penis development that occurs in about 1% of male births and its incidence is increasing at an alarming rate. One potential cause is environmental endocrine disruptors, chemicals we are constantly exposed to in our everyday lives. They are found in everything from plastic packaging to fresh fruit and vegetables, cosmetics and furniture. It is virtually impossible to avoid exposure to endocrine disruptors.
We use mouse genital tissue explants combined with morphometric and genomic analyses, to study how the normal penis develops and how endocrine disruptors interfere with this process as a cause of hypospadias.