CHP seminar: 11th June 2019 – Clinical and economic outcomes of using whole genome sequencing to contain a serious bacterial outbreak

12:30pm-1:30pm, Tuesday 11th June 2019
Seminar Room 410, 207 Bouverie Street, Carlton

Presenter: A/Prof. Louisa Gordon

There are ~165,000 hospital-acquired infections each in Australia. Whole genome sequencing (WGS) of pathogens can quickly confirm suspected cases of infectious disease, discriminate between strains and classify novel pathogens. The goal of the economic evaluation was to understand the role of WGS in managing patients exposed to a serious bacterial outbreak that occurred at the Princess Alexandra Hospital.

We compared using WGS as occurred in practice (delayed use) with using WGS earlier, along with several other scenarios, to determine the relative costs and benefits of these strategies. A hybrid agent-based and discrete event simulation model was used and a network approach was taken to encompass the hospital environment, dynamics of pathogen transmission, patient movements and actual hospital outbreak processes. The model inputs were hospital outbreak data provided by clinical staff, administrative data from the Queensland Hospital Admitted Patients Data Collection and other published evidence.

For more details, please view the event flyer

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