Susceptibilis: the land of complete susceptibility
By Ekmini Ramanayaka Pathirannehelage, Class of 2020.
Imagine that in the middle of the Pacific Ocean there is an island called ‘Susceptibilis’. It has a population of 150 people. Measles isn’t a problem on this island and no one is vaccinated against it. Suddenly, seemingly out of the blue, a case of measles pops up in the west of the island. A returned traveller develops a high fever, a runny nose and watery eyes. Several days later his body erupts in a nasty rash. Measles has hit.
Epidemiologist hats on! Let’s have a quick look at what’s happened.
An index case is found
Our returned traveller is, in this case, our index case. The index case is the very first case that the authorities become aware of. For Susceptibilis, this index case may also be our primary case because measles was never seen in the population before this. However, for some disease outbreaks, we actually may never figure out who the very first person to catch the disease was. We now have to think about where the traveller has been, who he has been in contact with. Essentially we need to do some contact tracing to find and isolate any other cases in the community. It’s something that’s easier said than done. It really helps to know how the disease behaves and how it’s transmitted.
The Basic Reproduction Number
Something we do sometimes know about diseases is the basic reproduction number. R0 (pronounced ‘R naught’), gives us an idea of just how contagious an infectious disease can be when there is no immunity for it in a population. R0 can also be used to help us figure out how many people need to be vaccinated to create herd immunity.
Measles is one of the most contagious diseases that we know of and has a very high R0 value, generally estimated to be somewhere between 12-18. This means that one infected person can go on to infect between 12 to 18 people if nothing is done and the disease is given free rein. In Susceptibilis, with no one being immune to the disease, there’s a good chance that measles will spread very quickly unless something is done. This is why vaccinations are really important. Preventing measles is all we have against it. There isn’t a specific medicine yet to treat it and you can only really treat symptoms.
R0 not as simple as it seems
In real life, estimating R0 isn’t as easy as shown in a textbook or classroom with a hypothetical case. Infectious disease modelling has to take into account a number of factors. In any population, there are births and deaths. People migrate and different diseases come and go. Seasons change and so do people’s behaviours. For some diseases, people are contagious before they even know they have the disease. So models can only provide good estimates and although there is some degree of uncertainty, they are really important for making informed decisions.
The story I’ve presented here is an extremely simple snippet. There is much more to a disease outbreak than just knowing the basic reproduction number and who the index case is. If you’d like to delve deeper, here are some places you could start:
(This book was my first brush with Epidemiology)